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On a day like today, Nobel Prize laureate John Vane was born
March 29, 1927. Sir John Robert Vane (29 March 1927 - 19 November 2004) was a British pharmacologist who was instrumental in the understanding of how aspirin produces pain-relief and anti-inflammatory effects and his work led to new treatments for heart and blood vessel disease and introduction of ACE inhibitors. He was awarded the Nobel Prize in Physiology or Medicine in 1982 along with Sune Bergström and Bengt Samuelsson for "their discoveries concerning prostaglandins and related biologically active substances". Vane held a post at the University of London for 18 years, progressing from senior lecturer to Professor of Experimental Pharmacology in 1966. During that time he developed certain bioassay techniques and focussed his research on both angiotensin-converting enzyme and the actions of aspirin, eventually leading to the publication with Priscilla Piper of the relationship between aspirin and the prostaglandins that earned him the Nobel Prize in Physiology or Medicine in 1982.



 


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