Established in 2020 Saturday, February 24, 2024

Pioneering new technique to barcode cells
The ground-breaking new technique allows scientists to carry out intricate and in-depth analysis of single cells, including mammalian cells, in real-time. Image: Unsplash.

EXETER.- Scientists have developed a pioneering new technique to barcode individual cells more accurately and efficiently—which could help pave the way for quicker disease diagnosis.

A team of researchers from the Living Systems Institute at the University of Exeter has created a new method, that combines artificial intelligence with microfluidics, that can easily classify, sort and count individual cells.

The ground-breaking new technique allows scientists to carry out intricate and in-depth analysis of single cells, including mammalian cells, in real-time.

Previously, there have been no general methods to accurately sample and barcode isolated single cells without large wastage during the sampling process.

This new approach, however, allows scientists to barcode individual cells much more accurately and efficiently than before to quantify their molecular make-up—a crucial development as disease often comes from the malfunction of a few cells.

The new technique could revolutionize the crucial early diagnosis of some of the most debilitating and life-threatening diseases, including cancer.

The study was published in the journal Advanced Materials Technologies.

Dr. Fabrice Gielen, principal investigator of the research group from the Living Systems Institute said: "With the technology we have developed, we have the opportunity to advance our understanding of the origin of differences observed between cells in a population."

"These differences are seen at the molecular level and are especially large during key cell stages such as differentiation into specialized cells, but can also be indicative of early cancer development."

"We have applied our tool for screening of thousands of single cells from real-time imaging data and efficiently barcode them with minimum cell waste."

"We are currently applying this tool to screen miniature in-vitro tumors formed from model neuroblastoma cells to understand why cancer progression appears to be highly unpredictable in clinical settings. This may lead to early diagnostics and the use of targeted therapeutics."

"Our technique being generic in scope, we also foresee plenty of further opportunities enabled by real-time image analyses such as the study of bacterial biofilm formation and the degradation of plastic microfibers by biocatalysts."

Today's News

December 18, 2021

'Mini-brains' provide clues about early life origins of schizophrenia

Sauropod dinosaurs were restricted to warmer regions of Earth

HKUMed finds Omicron SARS-CoV-2 can infect faster and better than Delta in human bronchus

Gene mutation leads to epileptic encephalopathy symptoms, neuron death in mice

Opening a 50-year-old Christmas present from the moon

Selective separation could help alleviate critical metals shortage

To build the quantum internet, UChicago engineer teaches atoms how to remember

Cambridge coronavirus vaccine enters clinical trial

Stanford engineers and physicists study quantum characteristics of 'combs' of light

To find energetic particles from space, a new detector will soar over Antarctic ice

Differences in brain structure and genetics linked to chronic pain

Are black holes and dark matter the same?

After thousands of years, an iconic whale confronts a new enemy

Wearable sensor measures airborne nicotine exposure from e-cigarettes

Pioneering new technique to barcode cells

Discovering sources of Roman silver coinage from the Iberian Peninsula

The climate system relies on microscopic particles

Giving bug-like bots a boost


Editor & Publisher: Jose Villarreal
Art Director: Juan José Sepúlveda Ramírez

Tell a Friend
Dear User, please complete the form below in order to recommend the ResearchNews newsletter to someone you know.
Please complete all fields marked *.
Sending Mail
Sending Successful