Established in 2020 Sunday, April 2, 2023

Micro-device could pick up early signs of heart attack or stroke
Using a pin-prick test, the micro-device would take a blood sample from a person's finger. Image courtesy: University of Sydney.

SYDNEY.- In Australia each year, approximately 55,000 people suffer a heart attack, with a similar number suffering from stroke. Many are caused by blood clots that block the flow of blood to the heart, often in at-risk individuals without any physical warning.

However, long before a heart attack or stroke occurs, tiny changes in the blood begin taking place. Often, blood flow is disturbed, leading to blood clotting and inflammation which can block blood vessels.

Award-winning University of Sydney biomedical engineer Dr. Arnold Lining Ju is developing a biomedical micro-device to detect these subtle platelet changes before a heart attack or stroke takes place.

Using a pin-prick test, the micro-device would take a blood sample from a person's finger. The sample would then be analyzed for platelet clotting and white cell inflammation responses, information that would be immediately processed by an external operating system.

"How this device would work is that an at-risk person, for example, someone with heart disease, would use it daily," said Dr. Ju from the Sydney Nanoscience Hub and Faculty of Engineering.

"Using a finger prick test, the device would monitor their blood and alert them to any potentially dangerous changes. If a change was detected, they would need to present for more monitoring at a hospital," said Dr. Ju, who is also a group affiliate of the Heart Research Institute's Thrombosis Group.

The research forms part of a long-term collaboration with the Director of Cardiovascular Research, CPC at the Heart Research Institute, Professor Shaun Jackson.

Professor Jackson said: "We hope this device will shed light on why and how blood clots form, which if successful, could one day be used in a range of health scenarios."

The University's School of Biomedical Engineering's new facilities will enable further engineering development for the microdevice, which is predicated on an integrated microfluidic chip.

Dr. Ju is working with a team of Ph.D. students to build highly sensitive computational fluid dynamics simulations to better understand the impact of mechanical forces that could lead to blood pooling and clots.

Biomedical engineering student Yunduo Charles Zhao said: "In the near future, we plan to apply artificial intelligence to understand an individual's blood work with the aim of creating a personalized blood profile of that person."

Research assistant Laura Moldovan said that, historically, it has been difficult to predict when a heart attack or stroke might happen: "They appear to occur at random, sometimes without any physical symptoms, however in fact there are tiny physical changes that occur in the blood—the key to this device is being able to sensitively monitor these microscopic changes."

Today's News

June 23, 2022

Canterbury suburbs were home to some of Britain's earliest humans, 600,000-year-old finds reveal

Micro-device could pick up early signs of heart attack or stroke

Breast cancer spreads at night

Light it up: Using firefly genes to understand cannabis biology

SeqScreen can reveal 'concerning' DNA

Unraveling sex determination in Bursaphelenchus nematodes: A path towards pest control

Improving the future of purification by using molecular silhouette to separate compounds in fluids

Robotic lightning bugs take flight

COVID-19 rebound after taking Paxlovid likely due to insufficient drug exposure

Technology helps self-driving cars learn from own memories

Erectile dysfunction drugs could help in the treatment of esophageal cancer

Systematic warming pool discovered in the Pacific due to human activities

A simple tool to make websites more secure and curb hacking

NASA's InSight gets a few extra weeks of Mars science

Another step toward synthetic cells

Researchers release open-source photorealistic simulator for autonomous driving

Study illuminates trade-off between complex words and complex sentences

Researcher shows how elliptical craters could shed light on age of Saturn's moons


Editor & Publisher: Jose Villarreal
Art Director: Juan José Sepúlveda Ramírez

Tell a Friend
Dear User, please complete the form below in order to recommend the ResearchNews newsletter to someone you know.
Please complete all fields marked *.
Sending Mail
Sending Successful